Recently, there has been increasing interest in Cordyceps fungi because of their purported properties in relation to cancer.
An article published in April 2026 in Molecular Nutrition & Food Research studied the effects of an extract high in cordycepin from Cordyceps militaris on lung cancer. Cordycepin is a natural compound produced by several species of Cordyceps. Research on the effects of cordycepin in inhibiting cancer cell proliferation has been ongoing for some time.
The findings of the 2026 research were positive for both laboratory and animal experiments. According to the researchers, the extract could not only stop the progress of the tumor, but also activate mechanisms of ferroptosis. Ferroptosis represents a form of regulated cell death resulting from iron-dependent damage to cell membranes. Scientists are becoming increasingly interested in this process, as it provides yet another mechanism by which to target cancer cells.
Nevertheless, we are still a long way from achieving this goal in clinical practice. The outcome of this study does not show that Cordyceps supplements can heal lung cancer in humans; further studies are needed to evaluate whether the same effects occur in humans and to determine safe and proper dosages.
In addition, there is an important difference between the standardized extracts used in research and the commercially sold Cordyceps dietary supplements available in stores, as the concentration of active components can vary widely.
People undergoing cancer treatment must inform their oncologists before using Cordyceps, as supplements may interact with prescribed medications. Furthermore, supplements must never be used to supplant prescribed medical treatments.
In summary, the study published in 2026 enhances the foundation built by past research on Cordyceps and its derivatives. While the laboratory outcomes are favorable, clinical human trials remain essential to confirm whether these compounds are safe and effective for patients.
Reference:
Boo, M., Sim, J. H., & Kim, H. J. (2026). Cordycepin-enriched Cordyceps militaris extract ARA815 induces ferroptosis in lung cancer cells in vivo and in vitro. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.70477
